Don't Bank on It:
The World's First "Made to Order Embryos"

This from The Daily Mail is just amazing. Welcome back to the Wild Wild West of Assisted Reproduction. Perhaps finally the ASRM will enact some sort of standards whereby clinics like this one in San Antonio are condemned, or at a minimum create what I've termed a "reproductive malpractice" network with clinicians whose statements with regard to ethical conduct are sworn and those who sign them agree to be deposed as necessary on the merits of the statement. Or maybe we should just let things go to this:
The world's first human embryo bank has been launched offering 'bespoke babies' for infertile couples.

For around £5,000 couples can buy ready-made embryos matched to their specific requirements - even down to choosing what eye and hair colour they would like their child to have.

In each case the embryos are made from eggs and sperm from two donors who have never even met. The moment of conception occurs in the laboratory and is determined by the genetic combination the clinic thinks will best meet the needs of the paying couples on its books.

Ethical campaigners last night condemned the move as the "absolute commercialisation of human life." They said it was heart-breaking that babies are now being treated as the equivalent of a supermarket "special offer".

Currently in the UK where one partner is infertile a couple can use donated sperm or eggs to create an embryo to be implanted in the woman's womb. Some couples can also use left-over embryos no longer needed by others who have undergone IVF.

But the new service is totally different as it allows couples to buy fresh embryos that fit their requirements but which have no biological link to either of them.

The human embryo bank is being run by The Abraham Center of Life in San Antonio in Texas. Although the clinic is in the USA, British women are expected to fly over for treatment.

It boasts that its sperm donors all have doctorate degrees and most of its egg donors have college degrees, are under 25 and healthy. So far most of the couples on its waiting lists are happy just to get an embryo and have not set out detailed requirements.

However some have asked for - and been allowed to join list of recipients that will get - embryos made from blond haired and blue eyed donors.

Whether a couple are put on the list for an existing embryo or one in the process of being created, they get 'portfolios' that include the donors' medical and social histories and usually a picture of them as a baby.

To create the embryos the chosen donor is given drugs to make her produce eggs and once collected they are combined with the selected sperm. Out of a single cycle of eggs several couples - each paying $10,000 (£5,300) - will each get two embryos for implantation.

Centre director Jennalee Ryan said already she has a waiting list of clients for embryos and so as soon as they become available they are spoken for. She said unlike other embryo donation or adoption schemes, these are not left-over embryos from infertile couples.

Because of the inherent problems that exist in such couples she said typically these only have a 30 per cent chance of producing a pregnancy. However she claimed the quality of the donor embryos she uses could offer double the chances of success.


Ms Ryan said the idea of the bank came out of her existing adoption service when she realised that many couples would be keen to use donated embryos to create a family that way instead. She said babies given up for adoption tend to come from lower social groups and there is often a history of drug or alcohol abuse.

However her egg and sperm donors are all well-educated and medically screened to ensure they have no health problems.

She said it was also cheaper than adoption or IVF with an egg donor which in the USA can cost up to $20,000 (£10,500). "It offers an opportunity for couples to have a child who could not otherwise afford it," she said.


Ms Ryan admitted some people especially religious groups have objected to the bank. "But what I say to them is Jesus was not conceived in the normal way either. I don't lose any sleep over what we are doing. I feel what we are doing is positive.

"We are helping couples and putting good genes back into the universe."

But Josephine Quintavalle of the UK campaigning group Comment on Reproductive Ethics said it amounted to the "absolute commercialisation of human life."

She said: "It is heartbreaking to see children reduced in this way to the equivalent of a special offer supermarket commodity. Cut price, tailor-made human embryos, complete with door to door delivery."

A spokeswoman for the Human Fertilisation and Embryology Authority said current rules would prevent any UK clinic from offering selection of embryos for non medical reasons [ed: is this true? . But she confirmed there is no law to stop women from Britain going to the USA for such treatment.

A big client will be all the ugly scientists of course. [hat tip to Art Caplan]

comments

The IVF procedure here is identical to the standard IVF using donated eggs. That's not the unique part of this system.
The selling point of this system is that they pre-screen the gamete donors ahead of time for genetic health, social success factors, and desirable genetic characteristics, and then match donors to increase the likelihood of genetic characteristics in the offspring that are desirable to the parents. (They're probably overselling this point, since the traits they're matching for are mostly polygenetic factors like eye color and, even more so, intelligence or attractiveness, for which they cannot realistically offer any guarantee.)
I can see no significant difference between this and the standard practices of almost all sperm banks - practices that have been in use now, without controversy, for decades. It is routine to screen sperm donors for inherited genetic diseases, as well as to offer potential buyers their choice of physical and social characteristics among donors. The same is done among egg donors, where recipients in some cases pay heavily for eggs from young women with desirable traits. The only difference in this case is that both the sperm and the eggs are from non-related donors, whereas in most cases of artificial insemination or IVF, a carefully screened and selected donor gamete is united with sperm or an egg from one member of the infertile couple. In the latter case, the control over genetic matching is restricted by the existing genes of the fertile parent, while it is possible to have greater (but still very limited) genetic control with a free choice among both egg and sperm, but other than that the process is identical. If we don't object to couples' doing comparison shopping for half their childrens' genes, I don't see how we can object to their doing exactly the same thing with greater efficacy.
There is one further step to which this technique lends itself: it would be possible not only to match the donor gametes to make chosen phenotypes more likely, but also to then conduct pre-implantation genetic diagnosis on the resulting embryos, not just for possible disease conditions but for undesirable eye color and so forth, allowing the couple to pick the embryo that is not only healthy but best satisfies their other desires as well. And, conceivably, some might object to this - though this also seems only a minor variation on practices already in place. But this does not seem to be part of the process outlined in the article above.
I can't see what the fuss is about.

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